It is important to be purposeful about creating a well-built clinical question so that you will be able to find the most relevant results possible. A well-built question will address four important items: Patient or Problem, Intervention, Comparison, and Outcome. To help you remember this, you can use the mnemonic PICO. When you are designing your clinical question, here are some topics to take into consideration.
From the University of Maryland Health Sciences and Human Services Library subject guide on Evidence-Based Practice. http://guides.hshsl.umaryland.edu/c.php?g=94009&p=609166.